Director / Senior Director, Program Management

Role Title: Director / Senior Director, Program Management

Status: Full Time; Exempt

Location: Remote USA

About Us

Enliven is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule therapeutics to help people not only live longer, but live better. Enliven aims to address existing and emerging unmet needs with a precision medicine approach that improves survival and enhances overall well-being. Enliven's discovery process combines deep insights into clinically validated biological targets and differentiated chemistry to design potentially first-in-class or best-in-class therapies.

Role Summary

Enliven Therapeutics is seeking an experienced, highly motivated, dynamic Director / Sr. Director, Program Management, to support our clinical programs. The ideal candidate will have experience working with cross-functional teams to drive strategy and thoughtful and robust execution of therapeutic programs. This individual serves as the operational leader of the cross-functional program team, ensuring alignment of strategy, timelines, resources, risks, and governance across Clinical Development, Regulatory, CMC, Biometrics, Medical Affairs, Commercial, Quality, and Corporate functions. The ideal candidate is a highly collaborative leader who blends deep biotech clinical development knowledge with expert project management skills. Reporting to the Vice President, Program Management, the ideal candidate will be go-getter, committed and excited to work in an energetic, fast-paced organization.

Key Responsibilities

Program Management & Execution

• Foster cross-functional alignment and facilitate operational excellence across Clinical Development, Regulatory Affairs, and CMC to ensure timely delivery of program milestones.
• Develop and maintain integrated timelines mapping out critical paths, regulatory filings (IND/NDA/BLA), and clinical milestones.
• Drive accountability across all relevant stakeholders by effectively communicating with the larger organization to ensure timely decision-making, risk management, and mitigations.
• Balance strategic thinking with disciplined execution to successfully advance programs through development and regulatory approval.

Governance & Communication

• Implement program management best practices, tools, and governance processes.
• Drive continuous improvement initiatives across development operations.
• Standardize planning methodologies, reporting, and metrics.
• Champion operational discipline across cross-functional teams.