Scientific Research Analyst (52613)

Position Objective: The Scientific Research Analyst will provide support services to satisfy the overall operational objectives of the National Institute of Environmental Health Sciences within the National Institutes of Health.

Duties and Responsibilities:

• Maintain and update computers associated with the X-ray facilities, and the individual workstations of NIEHS structural biologist 1
• Test, install, train, improve and design software related to crystallography, CryoEM, NMR andor graphical display of atomic structures 2
• Provide scientific support to structural biologist and other NIEHS scientists 3
• Work with and train users in methods and use of current software for crystal and CryoEM structure determination
• Work with staff on structure determination projects, particularly complex and difficult structure determinations
• Produce non-standard input files including but not limited to topology and parameter files for Phenix 4
• Work with staff on basic modeling of biochemical data on known atomic structures
• Write programs including but not limited to simple scripts, conversion programs, modification of software, and refinement programs
• Provide both technical recommendations on software usage and scientific advice about methods in x-ray structure determination including data processing, heavy-atom searching, phasing, model building, and refinement
• Produce publication quality, informative graphical representations of macromolecular structures, including use of available software, producing stereo pairs, and finding informative layouts for three-dimensional objects
• Work products and documents related to maintaining and updating computers associated with the X-ray facilities, and individual workstations of NIEHS staff involved in structural biology; testing, installing, training, improving and designing software related to crystallography, CryoEM, NMR and graphic display of atomic structures; providing support to staff.
• Work products and documents related to providing training and support in methods and use of software; working on structure determination projects; producing non-standard input files required for structural refinement; working on basic modeling of biochemical data on known atomic structures.
• Work products and documents related to writing programs, simple scripts, conversion
• programs, modification of software and refinement programs. Also provides written documentation for Materials and Methods of manuscripts prepared using output from assistance provided.
• Work products and documents related to providing technical recommendations about methods in X-ray structure determination, data processing, heavy-atom searching, phasing, model building and refinement; producing graphical representations. Also provides assistance to the structural biology community in refinement of CryoEM structures.