Sr. ADME and Quantitative Pharmacology Director
Description
Let’s build the future of medicine - together.
Join Enveda as a Sr. ADME and Quantitative Pharmacology Director and help us transform natural compounds into life-changing medicines. We’re a team driven by curiosity and innovation - are you ready to make a difference?
Remote | Full-Time | $340,000-$390,000
What Makes Us Enveda
Life is smart, and we can learn from it. We’re reinventing drug discovery by harnessing nature’s intelligence. Our platform identifies new medicines four times faster than the industry standard because patients can’t wait. What sets Enveda apart isn’t just what we do - it’s how we do it. Our culture is built on creativity, collaboration, and deep respect for each other. We believe “People Create All Value”, and our success is driven by the extraordinary team turning our mission into reality every day.
Our Momentum
- Unicorn status: Achieved following a $150 million Series D funding round in 2025
- Discovery and innovation: Advanced our first drug candidate to Phase 1 trials in 2024
- Award-winning culture:
- Newsweek: Top 100 Global #MostLovedWorkplaces (2025)
- Forbes: America’s Best Startup Employers (2024 & 2025)
- Newsweek: America’s Greatest Startup Workplaces (2025)
- Fast Company: Most Innovative Companies in 2026
These milestones reflect the impact of our team and we’re just getting started, but they’re only possible because of the diverse talent, perspectives, and relentless drive of our team, and people like you.
Your Role in Our Mission
At Enveda, every role drives impact. As the Sr. ADME and Quantitative Pharmacology Director, you’ll provide strategic leadership across DMPK, clinical pharmacology, and modeling & simulation for our expanding portfolio. You will be a key member of the AQP team, reporting to the VP, AQP, and will oversee DMPK and PK/PD activities from candidate nomination through clinical development - making significant contributions to integrated drug development strategy within a diverse R&D organization.
What You’ll Do
- Lead DMPK and PK/PD strategy across discovery and development programs, from candidate nomination through clinical development and regulatory submission
- Drive clinical pharmacology strategy including dose finding, exposure–response modeling, PK/PD analysis, and risk-benefit assessment for early- and late-stage programs
- Oversee PK/PD study design, analysis, and interpretation, collaborating with clinical operations, biostatistics, and regulatory colleagues
- Provide scientific and regulatory support for DMPK, Clinical Pharmacology, and Biopharmaceutics sections of regulatory submissions, including IND, NDA, and BLA filings
- Act as the subject-matter expert for clinical pharmacology and DMPK in interactions with FDA, EMA, and other global health authorities
- Partner with translational, discovery, and clinical teams to integrate nonclinical ADME data into clinical development plans and support compound progression from pipeline to early development
- Work closely with Discovery and DMPK groups to provide PK/ADME support for discovery projects, enabling informed compound selection and optimization
- Ensure alignment of DMPK and PK/PD activities with clinical development, drug manufacturing, and regulatory plans across the portfolio
- Provide strategic and technical leadership to the AQP function on scientific matters, combining full-time and consulting resources
- Plan and conduct stage-appropriate Clinical Pharmacology studies (Phase I/II/III) to support regulatory submissions
We’re Looking For
- PhD, PharmD, or MD in Pharmacokinetics, Clinical Pharmacology, Pharmaceutical Sciences, or a related discipline with 15+ years of relevant experience in biotech or pharma
- Demonstrated expertise in PK/PD, modeling & simulation, dose finding, and exposure-response strategies across nonclinical and clinical development
- Strong knowledge of Health Authority regulations and guidelines (ICH, FDA, EMA) for the development of small molecule therapies, with expert knowledge of those relating to Clinical Pharmacology/PK/PD
- Proven success representing Clinical Pharmacology and DMPK in regulatory interactions with FDA and ideally other regulators (e.g., FDA Pre-IND and EMA Scientific Advice meetings), and supporting IND, NDA, or BLA filings
- Extensive familiarity with major CROs and the ability to manage collaborations with CROs, academia, and industry partners
- Leadership experience managing teams and cross-functional collaborations, with excellent communication skills and the ability to influence at all levels from scientists to executive leadership
- Ability to manage multiple therapeutic programs in parallel and prioritize according to the needs of the company while delivering on key milestones
- Familiarity with non-oral small molecule delivery (formulation) approaches is a bonus; strong appreciation for research with a focus on product development
Enveda is protecting Job Seekers
We care deeply about creating a safe, respectful experience for every applicant, so we wanted to share a few guidelines to help you spot anything that doesn’t feel right.
- You’ll always meet real Enveda team members through video or in-person conversations before receiving an offer.
- All communication from us will come from an @enveda.com or @envedabio.com email address.
- We’ll never ask you to purchase equipment, send money, or share sensitive banking details as part of any step in our recruiting process.
If something feels off or you’re unsure whether a message is truly from Enveda, please reach out at anytime at recruiting@enveda.com.
As published by lever · 10 questions · 5 written answers
Basics
Resume/CV, Full name, Pronouns, Email, Phone, Current location, Current company, LinkedIn URL, GitHub URL, Other website
Pick from a list (5)
- (GDPR/CCPA) - Your personal data will be processed for recruiting related activities, which include setting up and conducting interviews and tests for applicants, evaluating and assessing the results thereto, and as is otherwise needed in the recruitment and hiring processes. Such processing is legally permissible under the GDPR (General Data Protection Regulation) and CCPA (California Consumer Privacy Act) as necessary for the purposes of the legitimate interests pursued by Enveda, which are the solicitation, evaluation, and selection of applicants for employment. Your personal data will be retained by Enveda as long as we determine necessary to evaluate your application for employment. You have the right to request access to your personal data, to request that your personal data be rectified or erased, and to request that processing of your personal data be restricted. optional
- (AI-assisted review) We believe that people create all value. That's why a real person reviews the hiring decisions that affect you. To keep up with the volume of applications we receive, we use an AI tool to help us read and organize applications against the requirements of the role. It helps us group and sort what people tell us so we can respond faster and more fairly. It does not have the final say. You can ask for a person to review your application instead, and you can ask us how your application was evaluated. optional
- Which best describes your degree and years of relevant experience in ADME, DMPK, or Clinical Pharmacology?
- How would you describe your experience with regulatory submissions and FDA or EMA interactions in a Clinical Pharmacology or DMPK capacity?
- What is your experience leading scientific teams or cross-functional collaborations as a senior DMPK or clinical pharmacology leader?
Written answers (5)
- Describe your expertise in PK/PD modeling and simulation, dose finding, and exposure-response analysis. What programs have you supported, what M&S approaches have you used, and what decisions did your work inform?
- Describe your experience integrating nonclinical ADME data into clinical development plans. How have you translated preclinical PK/ADME findings into dose selection, study design, or regulatory strategy for a clinical program?
- Describe your CRO management experience in a DMPK or clinical pharmacology context. How have you selected, governed, and held accountable external partners for key scientific deliverables?
- Describe how you have managed multiple therapeutic programs in parallel. How do you prioritize across programs with competing resource demands, and how do you ensure key milestones are delivered?
- What draws you to Enveda’s natural product drug discovery platform? How does your ADME and quantitative pharmacology expertise connect to the challenge of advancing structurally novel, nature-inspired molecules through development?