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University of South Florida

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Sr. Biological Scientist

Open 42d posting dated 2 weeks ago

The Advanced Scientist / Senior Sequencing Specialist plays a key role in the USF Genomics Sequencing Core, supporting Illumina Next-Generation Sequencing (NGS) and advanced single-cell and spatial transcriptomics sample preparation. This full-time position operates on a 9:00 AM–5:00 PM schedule and is responsible for ensuring efficient, high-quality daily operations within the Core. The incumbent will perform hands-on sequencing workflows, maintain rigorous quality standards, and ensure timely delivery of sequencing results while implementing best practices for reproducible and high-quality data generation.

Responsibilities:

  • Perform Next-Generation Sequencing (NGS) sample preparation and sequencing, including single-cell RNA-seq (scRNA-seq, snRNA-seq) and spatial transcriptomics (Visium HD) workflows, DNA/RNA library construction, Illumina sequencing, Nanopore sequencing, and Visium HD tissue sample preparation.
  • Operate and maintain high-throughput sequencing instruments (e.g., Illumina NovaSeq X, MiSeq i100) and single-cell systems (e.g., 10x Genomics Chromium X, Visium CytAssist).
  • Manage and prioritize daily laboratory workflow to ensure timely project completion within standard operating hours.
  • Conduct quality control (QC) assessments for RNA/DNA samples and sequencing libraries to ensure accuracy and integrity. Work closely with core users and internal team to troubleshoot, optimize protocols, and achieve consistent, high-quality results.
  • Maintain accurate documentation in iLab, including experimental records, billing, reagent usage, and equipment logs, ensuring compliance with institutional standards.
  • Contribute to laboratory training, SOP development, and continuous process improvement initiatives to enhance efficiency and performance.

Minimum Qualifications:

  • Master’s degree in Molecular Biology, Genomics, or a closely related field, and at least two (2) years of professional experience in a research or technical laboratory;
    or
  • Bachelor’s degree in a related field and at least five (5) years of relevant laboratory experience.

Preferred Qualifications:

  • Hands-on experience with NGS workflows, including DNA/RNA sequencing, single-cell, and spatial transcriptomics assays.
  • Hands-on experience with Illumina and/or Nanopore sequencing platforms.
  • Strong organizational and time-management skills to maintain daily operational efficiency and meet project deadlines.
  • Excellent teamwork, communication, and documentation skills.
  • Experience with 10x Genomics Chromium or Visium HD platforms is highly desirable.

Work Schedule:

Full-time, Monday through Friday, 9:00 AM–5:00 PM.

Compensation:

Commensurate with education and experience.

Application Instructions:

Interested candidates should submit a cover letter, resume/CV, and contact information for three professional references.

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