Postdoctoral Fellow-MSH-30020-171
Department: Stem Cell Biology & Regenerative Medicine
Physical work location: (must be proper street address) 619 West 54 Street, 8th floor
Name PI or Supervisor: (include phone and email) Joel Blanchard and joel.blanchard@mssm.edu
Web link to Lab:
Web link to Department: https://icahn.mssm.edu/about/departments/regenerative-biology
Administrative Contact: (phone and email) Nyomi Cepeda and nyomi.cepeda2@mssm.edu
Details of Research Project:
The Blanchard Laboratory is seeking highly skilled, creative, and motivated scientists to join our team studying how genetic and environmental factors shape the human brain’s vulnerability to neurodegenerative disease.
Our research focuses on uncovering the cellular and molecular mechanisms underlying Alzheimer’s disease and related neurodegenerative disorders, with the goal of identifying new therapeutic strategies. To accomplish this, the lab develops and applies advanced human iPSC-based brain models, including multicellular organoid and assembloid systems that recapitulate key aspects of human brain biology. These platforms are integrated with genomic, computational, and systems-level approaches to understand how genetic risk factors and environmental exposures drive disease processes.
Technical Duties: (include any protocols)
Projects in the laboratory span multiple areas of neurodegeneration research, including:
Genetic risk mechanisms in Alzheimer’s disease (e.g., APOE biology)
Neurovascular and glial contributions to neurodegeneration
Lipid metabolism and metabolic stress in the aging brain
Human brain organoid and assembloid engineering
Multi-omics analysis of human brain tissue and disease models
Our experimental platforms combine human iPSC models, post-mortem human brain analysis, and mouse models, enabling mechanistic discoveries that directly inform translational research.
Educational and other Requirements for the position: PhD
Experience Required: 4-5 years
Goals/Outcomes of the Research Project:
SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 865 - Cell Developmental & Regenerative Biology - ISM, Icahn School of Medicine